Five people suffered suspected drug overdoses and two men were allegedly caught with cocaine during Easter celebrations at Sydney's Ivy nightclub.
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Paramedics were called to five separate reports of drug overdoses within the George Street club between 9.52pm on Sunday and 12.53am on Monday.
Police will allege they later found two men using cocaine in the toilets.
Calls to help drug-affected people were made at 9.52pm, 10.15am. 11.34am, 12.48am and 12.53am, a NSW Ambulance spokeswoman said.
Police said four women and one man were taken to Sydney Hospital and St Vincent’s Hospital after allegedly overdosing on drugs which included cocaine, ecstasy, amphetamine and ketamine.
Ketamine is an anaesthetic drug sometimes used by veterinarians to sedate animals.
The two men accused of using cocaine were charged with possessing the drug and expected to appear in court at a later date.
Police say investigations into the supply of the drugs are ongoing.
Officers attached to an operation targeting alcohol-related crime during the long weekend arrested 130 people and laid 198 charges between Sunday night and Monday morning.
There were five people charged with assaulting police and 21 charged with common assault across NSW. Police said they inspected 827 businesses and detected 136 licence breaches and gave 24 people fines for failing to leave a licensed premises when asked to.
Forty-six people were charged with possession of a prohibited drug.
Operation Unite Commander, Superintendent Michael Fitzgerald, said he was pleased with the results but was concerned people continued to make poor choices.
"I am pleased with the results of the operation however it’s disappointing to see the number of people admitted to hospital suffering suspected drug overdoses. I’m urging people to be mindful of their actions and the potential consequences of engaging in illegal behaviour," he said.
